Proflora® 4R is a unique spore-forming (soil-based) probiotic with additional botanicals to support microbial balance and GI health.* The combination of quercetin, marshmallow root, and aloe vera extract in Proflora® 4R provide additional nutritional support for healthy microbial balance, with just one capsule per day, preferably at bedtime. Spore-forming probiotics are commensal bacteria found in our gastrointestinal tract. Unlike conventional probiotics, Proflora®4R does not require refrigeration, and is designed to survive stomach acid.